| Reaction Details |
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 | Report a problem with these data |
| Target | Lanosterol synthase |
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| Ligand | BDBM50051382 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_148911 (CHEMBL756148) |
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| IC50 | 16400±n/a nM |
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| Citation |  Barth, MM; Binet, JL; Thomas, DM; de Fornel, DC; Samreth, S; Schuber, FJ; Renaut, PP Structural and stereoelectronic requirements for the inhibition of mammalian 2,3-oxidosqualene cyclase by substituted isoquinoline derivatives. J Med Chem39:2302-12 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lanosterol synthase |
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| Name: | Lanosterol synthase |
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| Synonyms: | LSS_RAT | Lss | Osc |
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| Type: | PROTEIN |
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| Mol. Mass.: | 83302.12 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_12083 |
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| Residue: | 733 |
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| Sequence: | MTEGTCLRRRGGPYKTEPATDLTRWRLHNELGRQRWTYYQAEEDPGREQTGLEAHSLGLD
TTSYFKNLPKAQTAHEGALNGVTFYAKLQAEDGHWAGDYGGPLFLLPGLLITCHIAHIPL
PAGYREEMVRYLRSVQLPDGGWGLHIEDKSTVFGTALSYVSLRILGIGPDDPDLVRARNI
LHKKGGAVAIPSWGKFWLAVLNVYSWEGINTLFPEMWLLPEWFPAHPSTLWCHCRQVYLP
MSYCYATRLSASEDPLVQSLRQELYVEDYASIDWPAQKNNVCPDDMYTPHSWLLHVVYGL
LNLYERFHSTSLRKWAIQLLYEHVAADDRFTKCISIGPISKTVNMLIRWSVDGPSSPAFQ
EHVSRIKDYLWLGLDGMKMQGTNGSQTWDTSFAVQALLEAGAHRRPEFLPCLQKAHEFLR
LSQVPDNNPDYQKYYRHMHKGGFPFSTLDCGWIVADCTAEALKAVLLLQERCPSITEHVP
RERLYDAVAVLLSMRNSDGGFATYETKRGGYLLELLNPSEVFGDIMIDYTYVECTSAVMQ
ALRHFREYFPDHRATESRETLNQGLDFCRKKQRADGSWEGSWGVCFTYGTWFGLEAFACM
GHIYQNRTACAEVAQACHFLLSRQMADGGWGEDFESCEQRRYVQSAGSQVHSTCWALLGL
MAVRHPDISAQERGIRCLLGKQLPNGDWPQENISGVFNKSCAISYTNYRNIFPIWALGRF
SSLYPDNTLAGHI
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| BDBM50051382 |
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| n/a |
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| Name | BDBM50051382 |
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| Synonyms: | (6S,8aS)-2-Dodecyl-8a-methyl-1,2,3,5,6,7,8,8a-octahydro-isoquinolin-6-ol | CHEMBL421314 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H41NO |
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| Mol. Mass. | 335.567 |
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| SMILES | CCCCCCCCCCCCN1CC=C2C[C@@H](O)CC[C@]2(C)C1 |t:14| |
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| Structure | 
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