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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Prolyl endopeptidase | ||
| Ligand | BDBM50051485 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_158375 (CHEMBL769576) | ||
| IC50 | >100±n/a nM | ||
| Citation |  Portevin, B; Benoist, A; Rémond, G; Hervé, Y; Vincent, M; Lepagnol, J; De Nanteuil, G New prolyl endopeptidase inhibitors: in vitro and in vivo activities of azabicyclo[2.2.2]octane, azabicyclo[2.2.1]heptane, and perhydroindole derivatives. J Med Chem39:2379-91 (1996) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Prolyl endopeptidase | |||
| Name: | Prolyl endopeptidase | ||
| Synonyms: | PE | PEP | POP | PPCE_HUMAN | PREP | Post-proline cleaving enzyme | Prolyl oligopeptidase | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 80688.50 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P48147 | ||
| Residue: | 710 | ||
| Sequence: |
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| BDBM50051485 | |||
| n/a | |||
| Name | BDBM50051485 | ||
| Synonyms: | (S)-3-(Pyrrolidine-1-carbonyl)-2-aza-bicyclo[2.2.2]octane-2-carboxylic acid tert-butyl ester | CHEMBL75685 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C17H28N2O3 | ||
| Mol. Mass. | 308.4158 | ||
| SMILES | CC(C)(C)OC(=O)N1C2CCC(CC2)[C@H]1C(=O)N1CCCC1 |wU:14.16,(10.06,-15.21,;11.39,-15.99,;12.88,-16.39,;11.39,-17.53,;12.72,-15.22,;12.72,-13.68,;14.05,-12.91,;11.39,-12.91,;10.06,-13.67,;8.73,-12.91,;8.73,-11.37,;10.06,-10.59,;9.29,-11.92,;10.76,-11.51,;11.39,-11.37,;12.72,-10.6,;14.05,-11.37,;12.74,-9.06,;11.5,-8.15,;11.98,-6.68,;13.49,-6.67,;13.98,-8.15,)| | ||
| Structure | 
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