| Reaction Details |
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 | Report a problem with these data |
| Target | 60 kDa heat shock protein, mitochondrial |
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| Ligand | BDBM50028197 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1617698 (CHEMBL3859767) |
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| IC50 | >100000±n/a nM |
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| Citation |  Abdeen, S; Salim, N; Mammadova, N; Summers, CM; Goldsmith-Pestana, K; McMahon-Pratt, D; Schultz, PG; Horwich, AL; Chapman, E; Johnson, SM Targeting the HSP60/10 chaperonin systems of Trypanosoma brucei as a strategy for treating African sleeping sickness. Bioorg Med Chem Lett26:5247-5253 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 60 kDa heat shock protein, mitochondrial |
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| Name: | 60 kDa heat shock protein, mitochondrial |
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| Synonyms: | 3.6.4.9 | 60 kDa chaperonin | 60 kDa heat shock protein, mitochondrial | CH60_HUMAN | CPN60 | Chaperonin 60 | HSP-60 | HSP60 | HSP60/HSP10 | HSPD1 | Heat shock protein 60 | HuCHA60 | Mitochondrial matrix protein P1 | P60 lymphocyte protein |
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| Type: | PROTEIN |
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| Mol. Mass.: | 61050.41 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117701 |
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| Residue: | 573 |
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| Sequence: | MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGR
TVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLA
RSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDK
EIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQ
DAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAV
KAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKG
KGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDR
VTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIA
KNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLT
TAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF
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| BDBM50028197 |
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| n/a |
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| Name | BDBM50028197 |
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| Synonyms: | 2-(difluoromethyl)ornithine | CHEMBL830 | EFLORNITHINE |
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| Type | Small organic molecule |
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| Emp. Form. | C6H12F2N2O2 |
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| Mol. Mass. | 182.1685 |
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| SMILES | NCCCC(N)(C(F)F)C(O)=O |
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| Structure | 
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