| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50051910 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_54740 (CHEMBL667191) |
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| IC50 | 13±n/a nM |
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| Citation |  Gangjee, A; Vasudevan, A; Queener, SF; Kisliuk, RL 2,4-diamino-5-deaza-6-substituted pyrido[2,3-d]pyrimidine antifolates as potent and selective nonclassical inhibitors of dihydrofolate reductases. J Med Chem39:1438-46 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | Dihydrofolate reductase (F31V) | dfrA17 |
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| Type: | n/a |
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| Mol. Mass.: | 17532.46 |
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| Organism: | Escherichia coli |
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| Description: | n/a |
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| Residue: | 157 |
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| Sequence: | MKISLISAVSESGVIGSGPDIPWSVKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYA
VVSKNGISSSNENVLVFPSIENALKELSKVTDHVYVSGGGQIYNSLIEKADIIHLSTVHV
EVEGDIKFPIMPENFNLVFEQFFMSNINYTYQIWKKG
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| BDBM50051910 |
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| n/a |
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| Name | BDBM50051910 |
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| Synonyms: | (R)-4-Amino-5-(4-{[(2,4-diamino-pyrido[2,3-d]pyrimidin-6-yl)-methyl-amino]-methyl}-benzoylamino)-5-oxo-pentanoic acid | CHEMBL33815 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24N8O4 |
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| Mol. Mass. | 452.4665 |
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| SMILES | CN(Cc1ccc(cc1)C(=O)NC(=O)[C@H](N)CCC(O)=O)c1cnc2nc(N)nc(N)c2c1 |
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| Structure | 
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