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TargetDihydrofolate reductase
LigandBDBM50051919
Substrate/Competitorn/a
Meas. Tech.ChEMBL_54116 (CHEMBL668274)
IC50 76000±n/a nM
Citation Gangjee, AVasudevan, AQueener, SFKisliuk, RL 2,4-diamino-5-deaza-6-substituted pyrido[2,3-d]pyrimidine antifolates as potent and selective nonclassical inhibitors of dihydrofolate reductases. J Med Chem39:1438-46 (1996) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:Enzyme
Mol. Mass.:21453.99
Organism:Homo sapiens (Human)
Description:Recombinant human DHFR.
Residue:187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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BDBM50051919
n/a
NameBDBM50051919
Synonyms:CHEMBL33208 | N*6*-(3,4,5-Trimethoxy-benzyl)-pyrido[2,3-d]pyrimidine-2,4,6-triamine
TypeSmall organic molecule
Emp. Form.C17H20N6O3
Mol. Mass.356.3791
SMILESCOc1cc(CNc2cnc3nc(N)nc(N)c3c2)cc(OC)c1OC
Structure
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