Reaction Details |
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Target | Cytochrome P450 11B2, mitochondrial |
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Ligand | BDBM50502522 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1807730 (CHEMBL4307089) |
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IC50 | 24±n/a nM |
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Citation | Sparks, SM; Danger, DP; Hoekstra, WJ; Leesnitzer, T; Schotzinger, RJ; Yates, CM; Becherer, JD Development of Highly Selective Pyrimidine-Based Aldosterone Synthase (CYP11B2) Inhibitors. ACS Med Chem Lett10:1056-1060 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 11B2, mitochondrial |
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Name: | Cytochrome P450 11B2, mitochondrial |
Synonyms: | Aldosterone Synthase (CYP11B2) | Aldosterone synthase | Aldosterone-synthesizing enzyme | C11B2_HUMAN | CYP11B2 | CYPXIB2 | Cytochrome P450 11B2 | Cytochrome P450 11B2 (CYP11B2) | Cytochrome P450 11B2, mitochondrial | P-450Aldo | P-450C18 | Steroid 18-hydroxylase |
Type: | Protein |
Mol. Mass.: | 57582.15 |
Organism: | Homo sapiens (Human) |
Description: | P19099 |
Residue: | 503 |
Sequence: | MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN
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BDBM50502522 |
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n/a |
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Name | BDBM50502522 |
Synonyms: | CHEMBL4476351 |
Type | Small organic molecule |
Emp. Form. | C15H9F3N6 |
Mol. Mass. | 330.2674 |
SMILES | FC(F)(F)c1ncncc1-c1nc2ccc(nc2n1C1CC1)C#N |
Structure |
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