Reaction Details |
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Target | Sigma intracellular receptor 2 |
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Ligand | BDBM50502548 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1807839 (CHEMBL4307198) |
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Ki | 16±n/a nM |
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Citation | Zampieri, D; Fortuna, S; Calabretti, A; Romano, M; Menegazzi, R; Schepmann, D; Wünsch, B; Collina, S; Zanon, D; Mamolo, MG Discovery of new potent dual sigma receptor/GluN2b ligands with antioxidant property as neuroprotective agents. Eur J Med Chem180:268-282 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sigma intracellular receptor 2 |
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Name: | Sigma intracellular receptor 2 |
Synonyms: | S2r | SGMR2_RAT | Sigma intracellular receptor 2 | Sigma-2 receptor | Sigma2 receptor | Tmem97 | Transmembrane protein 97 |
Type: | Protein |
Mol. Mass.: | 20953.88 |
Organism: | Rattus norvegicus (Rat) |
Description: | Q5U3Y7 |
Residue: | 176 |
Sequence: | MGAVTARRCVEWLLGLYFVSHIPITMFIDLQALLPPELYPQEFSNLLRWYSKEFKDPLMQ
EPPVWFKSFLFCELVFQLPFFPIAAYAFFKGSCRWIRIPAIIYAVHTITTLIPILYTILF
EDFSKAIAFKGQRPENFRERLTLVGVYAPYLIIPLILLLFMLRNPYYKFEEKRKKK
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BDBM50502548 |
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n/a |
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Name | BDBM50502548 |
Synonyms: | CHEMBL4446466 |
Type | Small organic molecule |
Emp. Form. | C24H27N3O3 |
Mol. Mass. | 405.4895 |
SMILES | O=c1oc(nn1CCCCN1CCC2(CC1)OCc1ccccc21)-c1ccccc1 |
Structure |
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