| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tumor necrosis factor |
|---|
| Ligand | BDBM50052608 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_212401 (CHEMBL815988) |
|---|
| IC50 | 4700±n/a nM |
|---|
| Citation |  Muller, GW; Corral, LG; Shire, MG; Wang, H; Moreira, A; Kaplan, G; Stirling, DI Structural modifications of thalidomide produce analogs with enhanced tumor necrosis factor inhibitory activity. J Med Chem39:3238-40 (1996) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tumor necrosis factor |
|---|
| Name: | Tumor necrosis factor |
|---|
| Synonyms: | Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 25645.11 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P01375 |
|---|
| Residue: | 233 |
|---|
| Sequence: | MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
|
|
|
|---|
| BDBM50052608 |
|---|
| n/a |
|---|
| Name | BDBM50052608 |
|---|
| Synonyms: | 3-(3,4-Dimethoxy-phenyl)-3-(1,3-dioxo-1,3-dihydro-benzo[f]isoindol-2-yl)-propionic acid methyl ester | CHEMBL110956 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H21NO6 |
|---|
| Mol. Mass. | 419.4266 |
|---|
| SMILES | COC(=O)CC(N1C(=O)c2cc3ccccc3cc2C1=O)c1ccc(OC)c(OC)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
