Reaction Details |
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Target | Tumor necrosis factor |
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Ligand | BDBM50052613 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_212402 (CHEMBL815989) |
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IC50 | 7900±n/a nM |
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Citation | Muller, GW; Corral, LG; Shire, MG; Wang, H; Moreira, A; Kaplan, G; Stirling, DI Structural modifications of thalidomide produce analogs with enhanced tumor necrosis factor inhibitory activity. J Med Chem39:3238-40 (1996) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tumor necrosis factor |
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Name: | Tumor necrosis factor |
Synonyms: | Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha |
Type: | Enzyme |
Mol. Mass.: | 25645.11 |
Organism: | Homo sapiens (Human) |
Description: | P01375 |
Residue: | 233 |
Sequence: | MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
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BDBM50052613 |
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n/a |
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Name | BDBM50052613 |
Synonyms: | 3-(4,7-Dichloro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-(3,4-dimethoxy-phenyl)-propionic acid methyl ester | CHEMBL111544 |
Type | Small organic molecule |
Emp. Form. | C20H17Cl2NO6 |
Mol. Mass. | 438.258 |
SMILES | COC(=O)CC(N1C(=O)c2c(C1=O)c(Cl)ccc2Cl)c1ccc(OC)c(OC)c1 |
Structure |
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