| Reaction Details |
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 | Report a problem with these data |
| Target | Kelch-like ECH-associated protein 1 |
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| Ligand | BDBM50502733 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1808271 (CHEMBL4307630) |
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| EC50 | 2.0±n/a nM |
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| Citation |  Blass, BE Modulators of KEAP-1 Activity as Potential Therapies for the Treatment of Neurodegenerative Disorders. ACS Med Chem Lett10:1245-1246 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kelch-like ECH-associated protein 1 |
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| Name: | Kelch-like ECH-associated protein 1 |
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| Synonyms: | Cytosolic inhibitor of Nrf2 | INRF2 | KEAP1 | KEAP1/Cullin-3/Microtubule-associated protein tau | KEAP1_HUMAN | KIAA0132 | KLHL19 | Kelch-like protein 19 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 69664.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107924 |
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| Residue: | 624 |
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| Sequence: | MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
RSGVGVAVTMEPCRKQIDQQNCTC
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| BDBM50502733 |
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| n/a |
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| Name | BDBM50502733 |
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| Synonyms: | CHEMBL4446699 | US11479539, Compound 80 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H16FN3O2S |
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| Mol. Mass. | 357.402 |
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| SMILES | CO[C@]1(CC(C)(C)C(=O)C(=C1)C#N)c1ncc(F)cc1-c1ccns1 |r,c:9| |
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| Structure | 
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