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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase D1 | ||
| Ligand | BDBM158743 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1808275 (CHEMBL4307634) | ||
| Ki | <0.200000±n/a nM | ||
| Citation |  Feng, JA; Lee, P; Alaoui, MH; Barrett, K; Castanedo, G; Godemann, R; McEwan, P; Wang, X; Wu, P; Zhang, Y; Harris, SF; Staben, ST Structure Based Design of Potent Selective Inhibitors of Protein Kinase D1 (PKD1). ACS Med Chem Lett10:1260-1265 (2019) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase D1 | |||
| Name: | Serine/threonine-protein kinase D1 | ||
| Synonyms: | KPCD1_HUMAN | PKD | PKD1 | PRKCM | PRKD1 | Protein kinase C mu | Protein kinase C mu type | Protein kinase C mu type (PRKD1) | Protein kinase C, PKC; classical/novel | Protein kinase D | Protein kinase D (PRKD1) | Serine/threonine-protein kinase D1 (PKD1) | nPKC-D1 | nPKC-mu | ||
| Type: | Serine/threonine-protein kinase | ||
| Mol. Mass.: | 101705.07 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | gi_115529463 | ||
| Residue: | 912 | ||
| Sequence: |
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| BDBM158743 | |||
| n/a | |||
| Name | BDBM158743 | ||
| Synonyms: | US9034866, 218 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H23FN4O3 | ||
| Mol. Mass. | 446.4735 | ||
| SMILES | Cc1cc(no1)[C@](C)(O)C#Cc1cc2-c3nc(C(N)=O)c(C4CC4)n3C3CC(C3)c2cc1F |r,wU:6.8,wD:6.9,(-9.15,-.72,;-7.82,-1.49,;-6.57,-.59,;-5.32,-1.49,;-5.8,-2.96,;-7.34,-2.96,;-3.99,-.72,;-3.22,-2.06,;-5.32,.05,;-2.66,.05,;-1.32,.82,;.01,1.59,;1.34,.82,;2.68,1.59,;3.88,.63,;3.74,-.91,;5.16,-1.51,;5.56,-3,;4.47,-4.09,;7.05,-3.4,;6.17,-.35,;7.66,-.75,;8.75,-1.84,;9.15,-.35,;5.38,.97,;6.05,2.36,;5.38,3.75,;3.88,4.09,;4.56,2.76,;2.68,3.13,;1.34,3.9,;.01,3.13,;-1.32,3.9,)| | ||
| Structure | 
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