| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase VRK1 |
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| Ligand | BDBM50502749 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1808294 (CHEMBL4307653) |
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| Kd | 190±n/a nM |
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| Citation |  Serafim, RAM; de Souza Gama, FH; Dutra, LA; Dos Reis, CV; Vasconcelos, SNS; da Silva Santiago, A; Takarada, JE; Di Pillo, F; Azevedo, H; Mascarello, A; Elkins, JM; Massirer, KB; Gileadi, O; Guimarães, CRW; Couņago, RM Development of Pyridine-based Inhibitors for the Human Vaccinia-related Kinases 1 and 2. ACS Med Chem Lett10:1266-1271 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase VRK1 |
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| Name: | Serine/threonine-protein kinase VRK1 |
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| Synonyms: | VRK1 | VRK1_HUMAN | Vaccinia-related kinase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 45490.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1337676 |
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| Residue: | 396 |
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| Sequence: | MPRVKAAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSE
SVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHD
KNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA
SNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSR
RGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIA
KYMETVKLLDYTEKPLYENLRDILLQGLKAIGSKDDGKLDLSVVENGGLKAKTITKKRKK
EIEESKEPGVEDTEWSNTQTEEAIQTRSRTRKRVQK
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| BDBM50502749 |
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| n/a |
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| Name | BDBM50502749 |
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| Synonyms: | CHEMBL4435359 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H11F4NO2 |
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| Mol. Mass. | 349.2791 |
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| SMILES | Cc1ncc(cc1-c1cc(F)c(O)c(F)c1)-c1cc(F)c(O)c(F)c1 |
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| Structure | 
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