| Reaction Details |
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 | Report a problem with these data |
| Target | Reduced folate transporter |
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| Ligand | BDBM50503236 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1809823 (CHEMBL4309283) |
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| IC50 | 62±n/a nM |
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| Citation |  Ravindra, M; Wilson, MR; Tong, N; O'Connor, C; Karim, M; Polin, L; Wallace-Povirk, A; White, K; Kushner, J; Hou, Z; Matherly, LH; Gangjee, A Fluorine-Substituted Pyrrolo[2,3- d]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor ? and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis. J Med Chem61:4228-4248 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Reduced folate transporter |
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| Name: | Reduced folate transporter |
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| Synonyms: | FLOT1 | FOLT | Folate transporter 1 | IFC-1 | Intestinal folate carrier | Placental folate transporter | RFC | RFC1 | Reduced folate carrier protein | S19A1_HUMAN | SLC19A1 | Solute carrier family 19 member 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 64885.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1469594 |
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| Residue: | 591 |
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| Sequence: | MVPSSPAVEKQVPVEPGPDPELRSWRHLVCYLCFYGFMAQIRPGESFITPYLLGPDKNFT
REQVTNEITPVLSYSYLAVLVPVFLLTDYLRYTPVLLLQGLSFVSVWLLLLLGHSVAHMQ
LMELFYSVTMAARIAYSSYIFSLVRPARYQRVAGYSRAAVLLGVFTSSVLGQLLVTVGRV
SFSTLNYISLAFLTFSVVLALFLKRPKRSLFFNRDDRGRCETSASELERMNPGPGGKLGH
ALRVACGDSVLARMLRELGDSLRRPQLRLWSLWWVFNSAGYYLVVYYVHILWNEVDPTTN
SARVYNGAADAASTLLGAITSFAAGFVKIRWARWSKLLIAGVTATQAGLVFLLAHTRHPS
SIWLCYAAFVLFRGSYQFLVPIATFQIASSLSKELCALVFGVNTFFATIVKTIITFIVSD
VRGLGLPVRKQFQLYSVYFLILSIIYFLGAMLDGLRHCQRGHHPRQPPAQGLRSAAEEKA
AQALSVQDKGLGGLQPAQSPPLSPEDSLGAVGPASLEQRQSDPYLAQAPAPQAAEFLSPV
TTPSPCTLCSAQASGPEAADETCPQLAVHPPGVSKLGLQCLPSDGVQNVNQ
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| BDBM50503236 |
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| n/a |
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| Name | BDBM50503236 |
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| Synonyms: | CHEMBL4538151 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22FN5O6 |
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| Mol. Mass. | 459.4277 |
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| SMILES | Nc1nc2[nH]c(CCCc3ccc(C(=O)N[C@@H](CCC(O)=O)C(O)=O)c(F)c3)cc2c(=O)[nH]1 |r| |
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| Structure | 
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