Reaction Details |
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Target | Proton-coupled folate transporter |
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Ligand | BDBM50171511 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1809834 (CHEMBL4309294) |
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Ki | 460±n/a nM |
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Citation | Ravindra, M; Wilson, MR; Tong, N; O'Connor, C; Karim, M; Polin, L; Wallace-Povirk, A; White, K; Kushner, J; Hou, Z; Matherly, LH; Gangjee, A Fluorine-Substituted Pyrrolo[2,3- d]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor ? and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis. J Med Chem61:4228-4248 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Proton-coupled folate transporter |
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Name: | Proton-coupled folate transporter |
Synonyms: | G21 | HCP1 | Heme carrier protein 1 | PCFT | PCFT/HCP1 | PCFT_HUMAN | SLC46A1 | Solute carrier family 46 member 1 |
Type: | PROTEIN |
Mol. Mass.: | 49782.13 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1469597 |
Residue: | 459 |
Sequence: | MEGSASPPEKPRARPAAAVLCRGPVEPLVFLANFALVLQGPLTTQYLWHRFSADLGYNGT
RQRGGCSNRSADPTMQEVETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLA
SLGLLLQALVSVFVVQLQLHVGYFVLGRILCALLGDFGGLLAASFASVADVSSSRSRTFR
MALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFGETLKEPKST
RLFTFRHHRSIVQLYVAPAPEKSRKHLALYSLAIFVVITVHFGAQDILTLYELSTPLCWD
SKLIGYGSAAQHLPYLTSLLALKLLQYCLADAWVAEIGLAFNILGMVVFAFATITPLMFT
GYGLLFLSLVITPVIRAKLSKLVRETEQGALFSAVACVNSLAMLTASGIFNSLYPATLNF
MKGFPFLLGAGLLLIPAVLIGMLEKADPHLEFQQFPQSP
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BDBM50171511 |
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n/a |
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Name | BDBM50171511 |
Synonyms: | (S)-2-(4-(4-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)butyl)benzamido)pentanedioic acid | (S)-2-{4-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-butyl]-benzoylamino}-pentanedioic acid | CHEMBL365307 | N-{4-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)butyl]benzoyl}-L-glutamic Acid |
Type | Small organic molecule |
Emp. Form. | C22H25N5O6 |
Mol. Mass. | 455.4638 |
SMILES | Nc1nc2[nH]c(CCCCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cc2c(=O)[nH]1 |r| |
Structure |
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