| Reaction Details |
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 | Report a problem with these data |
| Target | Isocitrate dehydrogenase [NADP], mitochondrial |
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| Ligand | BDBM279948 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1809922 (CHEMBL4309382) |
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| IC50 | 7.0±n/a nM |
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| Citation |  Ma, T; Zou, F; Pusch, S; Xu, Y; von Deimling, A; Zha, X Inhibitors of Mutant Isocitrate Dehydrogenases 1 and 2 (mIDH1/2): An Update and Perspective. J Med Chem61:8981-9003 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Isocitrate dehydrogenase [NADP], mitochondrial |
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| Name: | Isocitrate dehydrogenase [NADP], mitochondrial |
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| Synonyms: | IDH2 | IDH2 (R172K, 40-end) | IDHP_HUMAN | Isocitrate dehydrogenase 2 (IDH2) |
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| Type: | Protein |
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| Mol. Mass.: | 50923.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Full-length wild-type |
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| Residue: | 452 |
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| Sequence: | MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTR
IIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDE
ARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYK
ATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAI
QKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKS
SGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQK
GRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIH
GLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ
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| BDBM279948 |
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| n/a |
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| Name | BDBM279948 |
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| Synonyms: | US10028961, Compound 101 | US10172864, Compound 101 | US10946023, Compound 101 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H13ClF6N6 |
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| Mol. Mass. | 414.737 |
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| SMILES | C[C@@H](Nc1nc(N[C@H](C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F |r| |
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| Structure | 
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