Reaction Details |
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Target | Isocitrate dehydrogenase [NADP], mitochondrial |
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Ligand | BDBM50503278 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1809914 (CHEMBL4309374) |
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IC50 | 32±n/a nM |
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Citation | Ma, T; Zou, F; Pusch, S; Xu, Y; von Deimling, A; Zha, X Inhibitors of Mutant Isocitrate Dehydrogenases 1 and 2 (mIDH1/2): An Update and Perspective. J Med Chem61:8981-9003 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Isocitrate dehydrogenase [NADP], mitochondrial |
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Name: | Isocitrate dehydrogenase [NADP], mitochondrial |
Synonyms: | IDH2 | IDH2 (R172K, 40-end) | IDHP_HUMAN | Isocitrate dehydrogenase 2 (IDH2) |
Type: | Protein |
Mol. Mass.: | 50923.31 |
Organism: | Homo sapiens (Human) |
Description: | Full-length wild-type |
Residue: | 452 |
Sequence: | MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTR
IIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDE
ARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYK
ATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAI
QKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKS
SGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQK
GRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIH
GLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ
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BDBM50503278 |
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n/a |
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Name | BDBM50503278 |
Synonyms: | CHEMBL4456102 | US10745383, Example 3 |
Type | Small organic molecule |
Emp. Form. | C19H17F6N7O |
Mol. Mass. | 473.375 |
SMILES | CC(C)(C)ONc1nc(Nc2ccnc(c2)C(F)(F)F)nc(n1)-c1cccc(n1)C(F)(F)F |
Structure |
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