| Reaction Details |
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 | Report a problem with these data |
| Target | Glutaminase kidney isoform, mitochondrial |
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| Ligand | BDBM332752 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1809975 (CHEMBL4309435) |
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| IC50 | 25±n/a nM |
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| Citation |  Zimmermann, SC; Duvall, B; Tsukamoto, T Recent Progress in the Discovery of Allosteric Inhibitors of Kidney-Type Glutaminase. J Med Chem62:46-59 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutaminase kidney isoform, mitochondrial |
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| Name: | Glutaminase kidney isoform, mitochondrial |
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| Synonyms: | GLS | GLS1 | GLSK_HUMAN | Glutaminase 1 | K-glutaminase | KIAA0838 | L-glutamine amidohydrolase |
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| Type: | Protein |
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| Mol. Mass.: | 73471.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O94925 |
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| Residue: | 669 |
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| Sequence: | MMRLRGSGMLRDLLLRSPAGVSATLRRAQPLVTLCRRPRGGGRPAAGPAAAARLHPWWGG
GGWPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEG
KELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMD
MLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKK
QSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDL
GTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQ
FLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSI
EVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPA
KSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKL
DPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVE
VVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQT
VHKNLDGLL
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| BDBM332752 |
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| n/a |
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| Name | BDBM332752 |
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| Synonyms: | (2S)-2-[3-(Difluoromethoxy)phenyl]-2-methoxy-N-[6-[(3R)-3-(pyridazin-3-ylamino)pyrrolidin-1-yl]pyridazin-3-yl]acetamide | US10196382, Example 1 | US10577354, Example 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23F2N7O3 |
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| Mol. Mass. | 471.4599 |
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| SMILES | CO[C@H](C(=O)Nc1ccc(nn1)N1CC[C@H](C1)Nc1cccnn1)c1cccc(OC(F)F)c1 |r| |
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| Structure | 
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