Reaction Details |
| Report a problem with these data |
Target | Serine/threonine-protein kinase B-raf |
---|
Ligand | BDBM50503325 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1810141 (CHEMBL4309601) |
---|
IC50 | 390±n/a nM |
---|
Citation | El-Gamal, MI; Park, BJ; Oh, CH Synthesis, in vitro antiproliferative activity, and kinase inhibitory effects of pyrazole-containing diarylureas and diarylamides. Eur J Med Chem156:230-239 (2018) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Serine/threonine-protein kinase B-raf |
---|
Name: | Serine/threonine-protein kinase B-raf |
Synonyms: | B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1 |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 84446.00 |
Organism: | Homo sapiens (Human) |
Description: | P15056 |
Residue: | 766 |
Sequence: | MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
|
|
|
BDBM50503325 |
---|
n/a |
---|
Name | BDBM50503325 |
Synonyms: | CHEMBL4436746 |
Type | Small organic molecule |
Emp. Form. | C30H20ClF6N5O2 |
Mol. Mass. | 631.956 |
SMILES | COc1cc(Cl)cc(c1)-c1nn(cc1-c1ccncc1)-c1cccc(NC(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c1 |
Structure |
|