Reaction Details |
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Target | Folylpolyglutamate synthase, mitochondrial |
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Ligand | BDBM50054214 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_68518 (CHEMBL676942) |
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IC50 | >200000±n/a nM |
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Citation | Mao, Z; Pan, J; Kalman, TI Design and synthesis of histidine analogues of folic acid and methotrexate as potential folylpolyglutamate synthetase inhibitors. J Med Chem39:4340-4 (1996) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Folylpolyglutamate synthase, mitochondrial |
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Name: | Folylpolyglutamate synthase, mitochondrial |
Synonyms: | FOLC_HUMAN | FPGS | Folylpoly-gamma-glutamate synthetase | Folylpolyglutamate synthase, mitochondrial | Tetrahydrofolate synthase | Tetrahydrofolylpolyglutamate synthase |
Type: | PROTEIN |
Mol. Mass.: | 64621.95 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_68676 |
Residue: | 587 |
Sequence: | MSRARSHLRAALFLAAASARGITTQVAARRGLSAWPVPQEPSMEYQDAVRMLNTLQTNAG
YLEQVKRQRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVTGTKGKGSTCAFTECILRS
YGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHRLEETKDGSCVSMPPYFRF
LTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIA
WQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCPMLEALEEGGPPLTLGLEGE
HQRSNAALALQLAHCWLQRQDRHGAGEPKASRPGLLWQLPLAPVFQPTSHMRLGLRNTEW
PGRTQVLRRGPLTWYLDGAHTASSAQACVRWFRQALQGRERPSGGPEVRVLLFNATGDRD
PAALLKLLQPCQFDYAVFCPNLTEVSSTGNADQQNFTVTLDQVLLRCLEHQQHWNHLDEE
QASPDLWSAPSPEPGGSASLLLAPHPPHTCSASSLVFSCISHALQWISQGRDPIFQPPSP
PKGLLTHPVAHSGASILREAAAIHVLVTGSLHLVGGVLKLLEPALSQ
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BDBM50054214 |
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n/a |
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Name | BDBM50054214 |
Synonyms: | 2-{4-[(2-Amino-4-hydroxy-pteridin-6-ylmethyl)-amino]-benzoylamino}-3-(1H-imidazol-4-yl)-propionic acid | CHEMBL137370 |
Type | Small organic molecule |
Emp. Form. | C20H19N9O4 |
Mol. Mass. | 449.4228 |
SMILES | Nc1nc2ncc(CNc3ccc(cc3)C(=O)NC(Cc3cnc[nH]3)C(O)=O)nc2c(=O)[nH]1 |
Structure |
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