| Reaction Details |
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 | Report a problem with these data |
| Target | Acyl-CoA:cholesterol acyltransferase |
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| Ligand | BDBM50054300 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_28664 (CHEMBL649062) |
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| IC50 | 9±n/a nM |
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| Citation |  White, AD; Creswell, MW; Chucholowski, AW; Blankley, CJ; Wilson, MW; Bousley, RF; Essenburg, AD; Hamelehle, KL; Krause, BR; Stanfield, RL; Dominick, MA; Neub, M Heterocyclic ureas: inhibitors of acyl-CoA:cholesterol O-acyltransferase as hypocholesterolemic agents. J Med Chem39:4382-95 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Acyl-CoA:cholesterol acyltransferase |
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| Name: | Acyl-CoA:cholesterol acyltransferase |
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| Synonyms: | ACAT |
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| Type: | n/a |
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| Mol. Mass.: | 35405.31 |
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| Organism: | Oryctolagus cuniculus |
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| Description: | n/a |
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| Residue: | 305 |
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| Sequence: | PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIF
VARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLP
TVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYI
VLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLF
APTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVL
VLCIF
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|
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| BDBM50054300 |
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| n/a |
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| Name | BDBM50054300 |
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| Synonyms: | 1-(2,6-Diisopropyl-phenyl)-3-(2-tridecyl-2,3-dihydro-1H-tetrazol-5-yl)-urea | CHEMBL336445 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H48N6O |
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| Mol. Mass. | 472.7096 |
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| SMILES | CCCCCCCCCCCCCN1NN=C(NC(=O)Nc2c(cccc2C(C)C)C(C)C)N1 |t:15| |
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| Structure | 
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