| Reaction Details |
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 | Report a problem with these data |
| Target | Protein mono-ADP-ribosyltransferase PARP12 |
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| Ligand | BDBM50503853 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1812389 (CHEMBL4311849) |
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| IC50 | >30000±n/a nM |
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| Citation |  Morgan, RK; Kirby, IT; Vermehren-Schmaedick, A; Rodriguez, K; Cohen, MS Rational Design of Cell-Active Inhibitors of PARP10. ACS Med Chem Lett10:74-79 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein mono-ADP-ribosyltransferase PARP12 |
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| Name: | Protein mono-ADP-ribosyltransferase PARP12 |
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| Synonyms: | ADP-ribosyltransferase diphtheria toxin-like 12 | ARTD12 | PAR12_HUMAN | PARP-12 | PARP12 | Poly [ADP-ribose] polymerase 12 | ZC3HDC1 | Zinc finger CCCH domain-containing protein 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 79092.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107665 |
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| Residue: | 701 |
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| Sequence: | MAQAGVVGEVTQVLCAAGGALELPELRRRLRMGLSADALERLLRQRGRFVVAVRAGGAAA
APERVVLAASPLRLCRAHQGSKPGCVGLCAQLHLCRFMVYGACKFLRAGKNCRNSHSLTT
EHNLSVLRTHGVDHLSYNELCQLLFQNDPWLLPEICQHYNKGDGPHGSCAFQKQCIKLHI
CQYFLQGECKFGTSCKRSHDFSNSENLEKLEKLGMSSDLVSRLPTIYRNAHDIKNKSSAP
SRVPPLFVPQGTSERKDSSGSVSPNTLSQEEGDQICLYHIRKSCSFQDKCHRVHFHLPYR
WQFLDRGKWEDLDNMELIEEAYCNPKIERILCSESASTFHSHCLNFNAMTYGATQARRLS
TASSVTKPPHFILTTDWIWYWSDEFGSWQEYGRQGTVHPVTTVSSSDVEKAYLAYCTPGS
DGQAATLKFQAGKHNYELDFKAFVQKNLVYGTTKKVCRRPKYVSPQDVTTMQTCNTKFPG
PKSIPDYWDSSALPDPGFQKITLSSSSEEYQKVWNLFNRTLPFYFVQKIERVQNLALWEV
YQWQKGQMQKQNGGKAVDERQLFHGTSAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARD
AAYSHHYSKSDTQTHTMFLARVLVGEFVRGNASFVRPPAKEGWSNAFYDSCVNSVSDPSI
FVIFEKHQVYPEYVIQYTTSSKPSVTPSILLALGSLFSSRQ
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| BDBM50503853 |
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| n/a |
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| Name | BDBM50503853 |
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| Synonyms: | CHEMBL4545565 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H13F3N2O |
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| Mol. Mass. | 306.2824 |
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| SMILES | Cc1c2CCNC(=O)c2ccc1-c1ccnc(c1)C(F)(F)F |
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| Structure | 
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