| Reaction Details |
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 | Report a problem with these data |
| Target | Proteinase-activated receptor 2 |
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| Ligand | BDBM50503927 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1812458 (CHEMBL4311918) |
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| IC50 | 480±n/a nM |
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| Citation |  Majewski, MW; Gandhi, DM; Rosas, R; Kodali, R; Arnold, LA; Dockendorff, C Design and Evaluation of Heterobivalent PAR1-PAR2 Ligands as Antagonists of Calcium Mobilization. ACS Med Chem Lett10:121-126 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proteinase-activated receptor 2 |
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| Name: | Proteinase-activated receptor 2 |
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| Synonyms: | F2RL1 | GPR11 | PAR2 | PAR2_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 44152.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1497756 |
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| Residue: | 397 |
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| Sequence: | MRSPSAAWLLGAAILLAASLSCSGTIQGTNRSSKGRSLIGKVDGTSHVTGKGVTVETVFS
VDEFSASVLTGKLTTVFLPIVYTIVFVVGLPSNGMALWVFLFRTKKKHPAVIYMANLALA
DLLSVIWFPLKIAYHIHGNNWIYGEALCNVLIGFFYGNMYCSILFMTCLSVQRYWVIVNP
MGHSRKKANIAIGISLAIWLLILLVTIPLYVVKQTIFIPALNITTCHDVLPEQLLVGDMF
NYFLSLAIGVFLFPAFLTASAYVLMIRMLRSSAMDENSEKKRKRAIKLIVTVLAMYLICF
TPSNLLLVVHYFLIKSQGQSHVYALYIVALCLSTLNSCIDPFVYYFVSHDFRDHAKNALL
CRSVRTVKQMQVSLTSKKHSRKSSSYSSSSTTVKTSY
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| BDBM50503927 |
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| n/a |
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| Name | BDBM50503927 |
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| Synonyms: | CHEMBL4470628 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H30FN5O4 |
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| Mol. Mass. | 495.5459 |
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| SMILES | CC(C)c1cc(nn2cc(nc12)C(=O)N1CCN(CC1(C)C)C(=O)CCC(O)=O)-c1ccc(F)cc1 |
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| Structure | 
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