| Reaction Details |
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 | Report a problem with these data |
| Target | Tubulin beta chain |
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| Ligand | BDBM50504214 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1814000 (CHEMBL4313574) |
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| IC50 | 700±n/a nM |
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| Citation |  Mustafa, M; Anwar, S; Elgamal, F; Ahmed, ER; Aly, OM Potent combretastatin A-4 analogs containing 1,2,4-triazole: Synthesis, antiproliferative, anti-tubulin activity, and docking study. Eur J Med Chem183:0 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tubulin beta chain |
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| Name: | Tubulin beta chain |
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| Synonyms: | Beta-tubulin | TBB_PIG | Tubulin beta chain |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49840.26 |
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| Organism: | Sus scrofa |
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| Description: | ChEMBL_105107 |
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| Residue: | 445 |
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| Sequence: | MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEGEEDEA
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| BDBM50504214 |
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| n/a |
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| Name | BDBM50504214 |
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| Synonyms: | CHEMBL4530425 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H21Cl2FN4O5 |
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| Mol. Mass. | 547.362 |
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| SMILES | COc1ccc(cc1Cl)-n1nc(nc1-c1cc(OC)c(OC)c(OC)c1)C(=O)Nc1ccc(F)c(Cl)c1 |
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| Structure | 
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