| Reaction Details |
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 | Report a problem with these data |
| Target | Polyunsaturated fatty acid lipoxygenase ALOX15 |
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| Ligand | BDBM50054846 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_208 (CHEMBL615242) |
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| IC50 | 320±n/a nM |
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| Citation |  Gorins, G; Kuhnert, L; Johnson, CR; Marnett, LJ (Carboxyalkyl)benzyl propargyl ethers as selective inhibitors of leukocyte-type 12-lipoxygenases. J Med Chem39:4871-8 (1997) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyunsaturated fatty acid lipoxygenase ALOX15 |
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| Name: | Polyunsaturated fatty acid lipoxygenase ALOX15 |
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| Synonyms: | 12-LOX | 12/15-lipoxygenase | 15-LOX | ALOX15 | Arachidonate 12-lipoxygenase | Arachidonate 12-lipoxygenase, leukocyte-type | Arachidonate omega-6 lipoxygenase | Erythroid cell-specific 15-lipoxygenase | LOX15_PIG |
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| Type: | PROTEIN |
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| Mol. Mass.: | 74999.86 |
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| Organism: | Sus scrofa |
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| Description: | ChEMBL_1510008 |
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| Residue: | 663 |
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| Sequence: | MGLYRVRVSTGSSFYAGSQNQVQLWLVGQHGEAALGWCLRPARGKETEFSVDVSEYLGPL
LFVKLRKRHLLQDDAWFCNWISVQGPGANGDEFRFPCYRWVEGDRILSLPEGTARTVVDD
PQGLFKKHREEELAERRKLYRWGNWKDGLILNIASTGIHDLPVDERFLEDKRIDFEASLA
KGLADLAVKDSLNVLMSWNSLDSFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGTNPM
LLRHSVELPARLKFPPGMEELQAQLEKELQGGTLFEADFSLLDGIKANVILCSQQYLAVP
LVMLKLQPDGKLLPMVIQLQLPHEGSPLPPLFLPTDPPMVWLLAKCWVRSSDFQLHELHS
HLLRGHLMAEVIAVATMRCLPSIHPIFKLLIPHFRYTMEINVRARNGLVSDLGIFDQVVS
TGGGGHVELLRRAAALLTYSSFCPPDDLADRGLLGVESSFYAQDALRLWEVISRYVEGIV
SLHYKTDESVKEDLELQAWCREFTEIGLLGAQDRGFPVSLQSKEQLCHFVTMCIFTCTGQ
HSSNHLGQLDWYSWVPNAPCTMRLPPPTTKDATLETVMATLPNFHQASLQMSITWQLGRC
QPTMVALGQHEEEYFSGPGPKAVLTKFREELAALDKDIEVRNAKLALPYEYLRPSRVENS
VAI
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| BDBM50054846 |
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| n/a |
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| Name | BDBM50054846 |
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| Synonyms: | 3-(4-Pentadec-2-ynyloxymethyl-phenyl)-propionic acid | CHEMBL341664 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H38O3 |
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| Mol. Mass. | 386.5674 |
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| SMILES | CCCCCCCCCCCCC#CCOCc1ccc(CCC(O)=O)cc1 |
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| Structure | 
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