Reaction Details |
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Target | Potassium-transporting ATPase alpha chain 1/subunit beta |
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Ligand | BDBM50056046 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_76070 (CHEMBL880098) |
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IC50 | 220±n/a nM |
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Citation | Terauchi, H; Tanitame, A; Tada, K; Nakamura, K; Seto, Y; Nishikawa, Y Nicotinamide derivatives as a new class of gastric H+/K(+)-ATPase inhibitors. 1. Synthesis and structure-activity relationships of N-substituted 2-(benzhydryl- and benzylsulfinyl)nicotinamides. J Med Chem40:313-21 (1997) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Potassium-transporting ATPase alpha chain 1/subunit beta |
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Name: | Potassium-transporting ATPase alpha chain 1/subunit beta |
Synonyms: | Potassium-transporting ATPase | Potassium-transporting ATPase alpha chain 1/beta chain |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 0 components. |
Component 1 |
Name: | Potassium-transporting ATPase subunit beta |
Synonyms: | ATP4B | ATP4B_PIG | Gastric H(+)/K(+) ATPase subunit beta | Potassium-transporting ATPase | Potassium-transporting ATPase beta chain | Potassium-transporting ATPase subunit beta | Proton pump beta chain | gp60-90 |
Type: | n/a |
Mol. Mass.: | 33083.09 |
Organism: | Sus scrofa (Pig) |
Description: | n/a |
Residue: | 290 |
Sequence: | MAALQEKKSCSQRMEEFQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMSGIFALCIY
VLMRTIDPYTPDYQDQLKSPGVTLRPDVYGEKGLDISYNVSDSTTWAGLAHTLHRFLAGY
SPAAQEGSINCTSEKYFFQESFLAPNHTKFSCKFTADMLQNCSGRPDPTFGFAEGKPCFI
IKMNRIVKFLPGNSTAPRVDCAFLDQPRDGPPLQVEYFPANGTYSLHYFPYYGKKAQPHY
SNPLVAAKLLNVPRNRDVVIVCKILAEHVSFDNPHDPYEGKVEFKLKIQK
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Component 2 |
Name: | Potassium-transporting ATPase alpha chain 1 |
Synonyms: | ATP4A | ATP4A_PIG | Gastric H(+)/K(+) ATPase subunit alpha | H+/K+-ATPase | Na/K-ATPase | Potassium-transporting ATPase | Potassium-transporting ATPase alpha chain 1 | Proton pump |
Type: | Enzyme |
Mol. Mass.: | 114279.23 |
Organism: | Sus scrofa (Pig) |
Description: | P19156 |
Residue: | 1034 |
Sequence: | MGKAENYELYQVELGPGPSGDMAAKMSKKKAGRGGGKRKEKLENMKKEMEINDHQLSVAE
LEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAI
CLIAFAIQASEGDLTTDDNLYLALALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQAT
VIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILQAQGRKVDNSSLTGESEPQTRSPE
CTHESPLETRNIAFFSTMCLEGTAQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEH
FVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKR
LASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHSADTTEDQSGQT
FDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGY
RERFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHVLVMKGAPERVLERCSSILIKGQELPL
DEQWREAFQTAYLSLGGLGERVLGFCQLYLSEKDYPPGYAFDVEAMNFPTSGLSFAGLVS
MIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRV
PVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGA
IVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFD
NLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESD
IMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRPQW
ENHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEMCQIADVLIRKTRRLSAFQQGFF
RNRILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPMPFGLLIFVYDEIRKLGV
RCCPGSWWDQELYY
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BDBM50056046 |
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n/a |
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Name | BDBM50056046 |
Synonyms: | 2-Pyridin-4-yl-isothiazolo[5,4-b]pyridin-3-one | CHEMBL323034 |
Type | Small organic molecule |
Emp. Form. | C11H7N3OS |
Mol. Mass. | 229.258 |
SMILES | O=c1n(sc2ncccc12)-c1ccncc1 |
Structure |
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