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TargetEDNRA
LigandBDBM50056060
Substrate/Competitorn/a
Meas. Tech.ChEMBL_63343
IC50 3.7±n/a nM
Citation Tasker ASSorensen BKJae HSWinn Mvon Geldern TWDixon DBChiou WJDayton BDCalzadila SHernandez LMarsh KCWuWong JROpgenorth TJ Potent and selective non-benzodioxole-containing endothelin-A receptor antagonists. J Med Chem 40:322-30 (1997) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
EDNRA
Name:Endothelin receptor
Synonyms:ENDOTHELIN A | Endothelin receptor | Endothelin-1 receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:48256.91
Organism:RAT
Description:ENDOTHELIN A EDNRA RAT::P26684
Residue:426
Sequence:
MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALP
SNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCM
LNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSS
HKDSMN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50056060
n/a
NameBDBM50056060
Synonyms:(2R,3R,4S)-1-Dibutylcarbamoylmethyl-4-(2,4-dimethoxy-phenyl)-2-(4-methoxy-phenyl)-pyrrolidine-3-carboxylic acid | CHEMBL112347
TypeSmall organic molecule
Emp. Form.C30H42N2O6
Mol. Mass.526.6643
SMILESCCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(OC)cc1)C(O)=O)c1ccc(OC)cc1OC
Structure
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