| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50056070 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_63343 (CHEMBL679285) |
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| IC50 | 1.5±n/a nM |
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| Citation |  Tasker, AS; Sorensen, BK; Jae, HS; Winn, M; von Geldern, TW; Dixon, DB; Chiou, WJ; Dayton, BD; Calzadila, S; Hernandez, L; Marsh, KC; WuWong, JR; Opgenorth, TJ Potent and selective non-benzodioxole-containing endothelin-A receptor antagonists. J Med Chem40:322-30 (1997) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA_RAT | ENDOTHELIN A | Ednra | Endothelin receptor | Endothelin-1 receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48256.91 |
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| Organism: | RAT |
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| Description: | ENDOTHELIN A EDNRA RAT::P26684 |
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| Residue: | 426 |
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| Sequence: | MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALP
SNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCM
LNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSS
HKDSMN
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| BDBM50056070 |
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| n/a |
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| Name | BDBM50056070 |
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| Synonyms: | (2R,3R,4S)-1-Dibutylcarbamoylmethyl-4-(3,4-difluoro-phenyl)-2-(4-methoxy-phenyl)-pyrrolidine-3-carboxylic acid | CHEMBL113400 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H36F2N2O4 |
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| Mol. Mass. | 502.5932 |
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| SMILES | CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(OC)cc1)C(O)=O)c1ccc(F)c(F)c1 |
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| Structure | 
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