| Reaction Details |
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 | Report a problem with these data |
| Target | Neutral cholesterol ester hydrolase 1 |
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| Ligand | BDBM50052768 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1821759 (CHEMBL4321419) |
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| IC50 | >100000±n/a nM |
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| Citation |  Otrubova, K; Chatterjee, S; Ghimire, S; Cravatt, BF; Boger, DL N-Acyl pyrazoles: Effective and tunable inhibitors of serine hydrolases. Bioorg Med Chem27:1693-1703 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutral cholesterol ester hydrolase 1 |
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| Name: | Neutral cholesterol ester hydrolase 1 |
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| Synonyms: | Aadacl1 | Arylacetamide deacetylase-like 1 | CPO-BP | Chlorpyrifos oxon-binding protein | Kiaa1363 | NCEH | NCEH1_MOUSE | Nceh1 | Neutral cholesterol ester hydrolase |
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| Type: | Single-pass type II membrane protein; hydrolase |
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| Mol. Mass.: | 45742.11 |
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| Organism: | Mus musculus (mouse) |
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| Description: | Assays were using membranes of recombinant KIAA1363 transiently transfected in COS-7 cells. |
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| Residue: | 408 |
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| Sequence: | MRSSCVLLAALLALAAYYVYIPLPSAVSDPWKLMLLDATFRGAQQVSNLIHSLGLNHHLI
ALNFIITSFGKQSARSSPKVKVTDTDFDGVEVRVFEGSPKPEEPLRRSVIYIHGGGWALA
SAKISYYDQLCTTMAEELNAVIVSIEYRLVPQVYFPEQIHDVIRATKYFLQPEVLDKYKV
DPGRVGISGDSAGGNLAAALGQQFTYVASLKNKLKLQALVYPVLQALDFNTPSYQQSMNT
PILPRHVMVRYWLDYFKGNYDFVEAMIVNNHTSLDVERAAALRARLDWTSLLPSSIKKNY
KPIMQTTGNARIVQEIPQLLDAAASPLIAEQEVLEALPKTYILTCEHDVLRDDGIMYAKR
LESAGVNVTLDHFEDGFHGCMIFTSWPTNFSVGIRTRNSYIKWLDQNL
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| BDBM50052768 |
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| n/a |
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| Name | BDBM50052768 |
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| Synonyms: | CHEMBL3318613 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23N5O2 |
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| Mol. Mass. | 401.461 |
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| SMILES | O=C(N1CCN(Cc2ccc(OCc3ccccc3)cc2)CC1)n1cc(cn1)C#N |
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| Structure | 
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