| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium channel subfamily K member 3 |
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| Ligand | BDBM50123519 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1822391 (CHEMBL4322155) |
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| IC50 | 7.0±n/a nM |
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| Citation |  Bedoya, M; Rinné, S; Kiper, AK; Decher, N; González, W; Ramírez, D TASK Channels Pharmacology: New Challenges in Drug Design. J Med Chem62:10044-10058 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium channel subfamily K member 3 |
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| Name: | Potassium channel subfamily K member 3 |
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| Synonyms: | Acid-sensitive potassium channel TASK-1 | Acid-sensitive potassium channel protein TASK-1 | KCNK3 | KCNK3_HUMAN | Potassium channel protein TASK-1 | Potassium channel subfamily K member 3 | Potassium channel subfamily K member 3 (TASK-1) | TASK | TASK1 | TWIK-related acid-sensitive K(+) channel 1 | Two pore K(+) channel KT3.1 | Two pore potassium channel KT3.1 |
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| Type: | Protein |
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| Mol. Mass.: | 43534.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O14649 |
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| Residue: | 394 |
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| Sequence: | MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPELIERQRLELRQQELRARYNLSQGGYE
ELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPL
TLVMFQSLGERINTLVRYLLHRAKKGLGMRRADVSMANMVLIGFFSCISTLCIGAAAFSH
YEHWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLN
LVVLRFMTMNAEDEKRDAEHRALLTRNGQAGGGGGGGSAHTTDTASSTAAAGGGGFRNVY
AEVLHFQSMCSCLWYKSREKLQYSIPMIIPRDLSTSDTCVEQSHSSPGGGGRYSDTPSRR
CLCSGAPRSAISSVSTGLHSLSTFRGLMKRRSSV
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| BDBM50123519 |
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| n/a |
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| Name | BDBM50123519 |
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| Synonyms: | 2'-{[2-(4-Methoxy-phenyl)-acetylamino]-methyl}-biphenyl-2-carboxylic acid 2,4-difluoro-benzylamide | CHEMBL148342 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H26F2N2O3 |
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| Mol. Mass. | 500.5358 |
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| SMILES | COc1ccc(CC(=O)NCc2ccccc2-c2ccccc2C(=O)NCc2ccc(F)cc2F)cc1 |
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| Structure | 
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