Ki Summary

Reaction Details

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Target

Nuclear receptor subfamily 5 group A member 2

Ligand

BDBM50418303

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1822631 (CHEMBL4322395)

EC50

600±n/a nM

Citation

Mays, SG; Flynn, AR; Cornelison, JL; Okafor, CD; Wang, H; Wang, G; Huang, X; Donaldson, HN; Millings, EJ; Polavarapu, R; Moore, DD; Calvert, JW; Jui, NT; Ortlund, EA Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design. J Med Chem62:11022-11034 (2019) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Nuclear receptor subfamily 5 group A member 2

Name:

Nuclear receptor subfamily 5 group A member 2

Synonyms:

Alpha-1-fetoprotein transcription factor | B1-binding factor | B1F | CPF | CYP7A promoter-binding factor | FTF | Hepatocytic transcription factor | LRH-1 | Liver Receptor Homolog 1 | NR5A2 | NR5A2_HUMAN | Nuclear receptor subfamily 5 group A member 2 | hB1F | nuclear receptor subfamily 5 group A member 2 isoform 2

Type:

Nuclear Hormone Receptor

Mol. Mass.:

61341.37

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

541

Sequence:

MSSNSDTGDLQESLKHGLTPIGAGLPDRHGSPIPARGRLVMLPKVETEALGLARSHGEQG
QMPENMQVSQFKMVNYSYDEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRY
TCIENQNCQIDKTQRKRCPYCRFQKCLSVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQ
QKKALIRANGLKLEAMSQVIQAMPSDLTISSAIQNIHSASKGLPLNHAALPPTDYDRSPF
VTSPISMTMPPHGSLQGYQTYGHFPSRAIKSEYPDPYTSSPESIMGYSYMDSYQTSSPAS
IPHLILELLKCEPDEPQVQAKIMAYLQQEQANRSKHEKLSTFGLMCKMADQTLFSIVEWA
RSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSIIASQA
GATLNNLMSHAQELVAKLRSLQFDQREFVCLKFLVLFSLDVKNLENFQLVEGVQEQVNAA
LLDYTMCNYPQQTEKFGQLLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHAKR
A

BDBM50418303

n/a

Name

BDBM50418303

Synonyms:

CHEMBL1765959

Type

Small organic molecule

Emp. Form.

C28H34O

Mol. Mass.

386.569

SMILES

CCCCCCC1=C(c2ccccc2)[C@@]2(CC[C@@H](O)[C@@H]2C1)C(=C)c1ccccc1 |r,c:6|

Structure