| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor subfamily 5 group A member 2 |
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| Ligand | BDBM50505380 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1822622 (CHEMBL4322386) |
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| EC50 | 500±n/a nM |
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| Citation |  Mays, SG; Flynn, AR; Cornelison, JL; Okafor, CD; Wang, H; Wang, G; Huang, X; Donaldson, HN; Millings, EJ; Polavarapu, R; Moore, DD; Calvert, JW; Jui, NT; Ortlund, EA Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design. J Med Chem62:11022-11034 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor subfamily 5 group A member 2 |
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| Name: | Nuclear receptor subfamily 5 group A member 2 |
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| Synonyms: | Alpha-1-fetoprotein transcription factor | B1-binding factor | B1F | CPF | CYP7A promoter-binding factor | FTF | Hepatocytic transcription factor | LRH-1 | Liver Receptor Homolog 1 | NR5A2 | NR5A2_HUMAN | Nuclear receptor subfamily 5 group A member 2 | hB1F | nuclear receptor subfamily 5 group A member 2 isoform 2 |
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| Type: | Nuclear Hormone Receptor |
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| Mol. Mass.: | 61341.37 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 541 |
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| Sequence: | MSSNSDTGDLQESLKHGLTPIGAGLPDRHGSPIPARGRLVMLPKVETEALGLARSHGEQG
QMPENMQVSQFKMVNYSYDEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRY
TCIENQNCQIDKTQRKRCPYCRFQKCLSVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQ
QKKALIRANGLKLEAMSQVIQAMPSDLTISSAIQNIHSASKGLPLNHAALPPTDYDRSPF
VTSPISMTMPPHGSLQGYQTYGHFPSRAIKSEYPDPYTSSPESIMGYSYMDSYQTSSPAS
IPHLILELLKCEPDEPQVQAKIMAYLQQEQANRSKHEKLSTFGLMCKMADQTLFSIVEWA
RSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSIIASQA
GATLNNLMSHAQELVAKLRSLQFDQREFVCLKFLVLFSLDVKNLENFQLVEGVQEQVNAA
LLDYTMCNYPQQTEKFGQLLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHAKR
A
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| BDBM50505380 |
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| n/a |
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| Name | BDBM50505380 |
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| Synonyms: | CHEMBL4541939 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H36N2O |
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| Mol. Mass. | 428.6089 |
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| SMILES | [H][C@@]12CC(CCCCCC)=C(c3ccccc3)[C@@]1(CC[C@@H]2NC(N)=O)C(=C)c1ccccc1 |r,t:9| |
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| Structure | 
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