Ki Summary

Reaction Details

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Target

Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

Ligand

BDBM50505542

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1823076 (CHEMBL4322840)

72±n/a nM

Citation

Hirozane, Y; Toyofuku, M; Yogo, T; Tanaka, Y; Sameshima, T; Miyahisa, I; Yoshikawa, M Structure-based rational design of staurosporine-based fluorescent probe with broad-ranging kinase affinity for kinase panel application. Bioorg Med Chem Lett29:0 (2019) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

Name:

Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

Synonyms:

PHKG2 | PHKG2_HUMAN | Phosphorylase kinase | Phosphorylase kinase gamma subunit 2

Type:

PROTEIN

Mol. Mass.:

46440.15

Organism:

Homo sapiens (Human)

Description:

ChEMBL_774277

Residue:

406

Sequence:

MTLDVGPEDELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAE
RLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLT
EKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEP
GEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQIL
MLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPW
NLTPRQRFRVAVWTVLAAGRVALSTHRVRPLTKNALLRDPYALRSVRHLIDNCAFRLYGH
WVKKGEQQNRAALFQHRPPGPFPIMGPEEEGDSAAITEDEAVLVLG

BDBM50505542

n/a

Name

BDBM50505542

Synonyms:

CHEMBL4576489

Type

Small organic molecule

Emp. Form.

C50H56BF2N7O7

Mol. Mass.

915.83

SMILES

[H][C@]12C[C@H]([C@@H](OC)[C@](C)(O1)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)CCOCCOCCOCCNC(=O)CCC1=[N+]2C(C=C1)=Cc1c(C)cc(C)n1[B-]2(F)F |r,c:63,65,t:60|

Structure