| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Sgk1 |
|---|
| Ligand | BDBM50505541 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1823016 (CHEMBL4322780) |
|---|
| Kd | 331±n/a nM |
|---|
| Citation |  Hirozane, Y; Toyofuku, M; Yogo, T; Tanaka, Y; Sameshima, T; Miyahisa, I; Yoshikawa, M Structure-based rational design of staurosporine-based fluorescent probe with broad-ranging kinase affinity for kinase panel application. Bioorg Med Chem Lett29:0 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase Sgk1 |
|---|
| Name: | Serine/threonine-protein kinase Sgk1 |
|---|
| Synonyms: | SGK | SGK1 | SGK1_HUMAN | Serine/threonine-protein kinase Sgk1 | Serine/threonine-protein kinase Sgk1 (SGK) | Serum/glucocorticoid regulated kinase | Serum/glucocorticoid-regulated kinase 1 (SGK1) |
|---|
| Type: | Other Protein Type |
|---|
| Mol. Mass.: | 48954.40 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Recombinant human SGK-1 enzyme produced in a baculovirus system. |
|---|
| Residue: | 431 |
|---|
| Sequence: | MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKI
SQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAE
EVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYIN
GGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTD
FGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR
NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINW
DDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLG
FSYAPPTDSFL
|
|
|
|---|
| BDBM50505541 |
|---|
| n/a |
|---|
| Name | BDBM50505541 |
|---|
| Synonyms: | CHEMBL4465866 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C49H54BF2N7O7 |
|---|
| Mol. Mass. | 901.804 |
|---|
| SMILES | [H][C@]12C[C@@H](NCCOCCOCCOCCNC(=O)CCC3=[N+]4C(C=C3)=Cc3c(C)cc(C)n3[B-]4(F)F)[C@@H](OC)[C@](C)(O1)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r,c:24,26,t:21| |
|---|
| Structure | 
|
|---|
Search and Browse
