| Reaction Details |
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 | Report a problem with these data |
| Target | Solute carrier family 22 member 1 |
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| Ligand | BDBM50001000 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1823590 (CHEMBL4323354) |
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| IC50 | 6000±n/a nM |
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| Citation |  Meyer, MJ; Neumann, VE; Friesacher, HR; Zdrazil, B; Brockmöller, J; Tzvetkov, MV Opioids as Substrates and Inhibitors of the Genetically Highly Variable Organic Cation Transporter OCT1. J Med Chem62:9890-9905 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Solute carrier family 22 member 1 |
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| Name: | Solute carrier family 22 member 1 |
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| Synonyms: | Adrenergic Alpha | OCT1 | Organic cation transporter 1 | S22A1_HUMAN | SLC22A1 | Solute carrier family 22 member 1 | hOCT1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 61154.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Adrenergic Alpha 0 HUMAN::O15245 |
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| Residue: | 554 |
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| Sequence: | MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQ
RCGWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGP
CQDGWVYDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLL
GTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMY
QMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIK
IMDHIAQKNGKLPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVL
YQGLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVM
IFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIIT
PFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAENLGRKAKPKEN
TIYLKVQTSEPSGT
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| BDBM50001000 |
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| n/a |
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| Name | BDBM50001000 |
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| Synonyms: | CHEBI:29133 | DEXTRORPHAN | US11535596, Compound Dextorphan (DX) |
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| Type | Small organic molecule |
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| Emp. Form. | C17H23NO |
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| Mol. Mass. | 257.3706 |
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| SMILES | [H][C@]12Cc3ccc(O)cc3[C@@]3(CCCC[C@]13[H])CCN2C |r,THB:20:19:15:2.9.3| |
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| Structure | 
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