| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 2 |
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| Ligand | BDBM50506134 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1824953 (CHEMBL4324717) |
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| Ki | 3.5±n/a nM |
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| Citation |  Ortiz Zacarķas, NV; van Veldhoven, JPD; den Hollander, LS; Dogan, B; Openy, J; Hsiao, YY; Lenselink, EB; Heitman, LH; IJzerman, AP Synthesis and Pharmacological Evaluation of Triazolopyrimidinone Derivatives as Noncompetitive, Intracellular Antagonists for CC Chemokine Receptors 2 and 5. J Med Chem62:11035-11053 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 2 |
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| Name: | C-C chemokine receptor type 2 |
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| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 41932.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41597 |
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| Residue: | 374 |
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| Sequence: | MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
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| BDBM50506134 |
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| n/a |
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| Name | BDBM50506134 |
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| Synonyms: | CHEMBL4471792 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H17N5O |
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| Mol. Mass. | 295.3391 |
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| SMILES | Cc1ccc(Cc2c([nH]c3nc(N)nn3c2=O)C2CC2)cc1 |
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| Structure | 
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