| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A1 |
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| Ligand | BDBM50058235 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_29297 (CHEMBL640358) |
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| Ki | 2.56±n/a nM |
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| Citation |  Pfister, JR; Belardinelli, L; Lee, G; Lum, RT; Milner, P; Stanley, WC; Linden, J; Baker, SP; Schreiner, G Synthesis and biological evaluation of the enantiomers of the potent and selective A1-adenosine antagonist 1,3-dipropyl-8-[2-(5,6-epoxynorbonyl)]-xanthine. J Med Chem40:1773-8 (1997) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A1 |
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| Name: | Adenosine receptor A1 |
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| Synonyms: | A1 adenosine receptor | AA1R_CAVPO | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | ADORA1 | Adenosine A1 receptor | Adenosine Receptor A1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 36501.39 |
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| Organism: | GUINEA PIG |
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| Description: | ADENOSINE A1 ADORA1 GUINEA PIG::P47745 |
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| Residue: | 326 |
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| Sequence: | MPHSVSAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIASLAVADVAVGA
LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVT
PRRAAVAIAGCWILSLVVGLTPMFGWNNLSKIEMAWAANGSVGEPVIKCEFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLSKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPTCHKPTILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFL
KIWNDHFRCQPEPPIDEDLPEEKVDD
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| BDBM50058235 |
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| n/a |
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| Name | BDBM50058235 |
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| Synonyms: | 8-(3-Oxa-tricyclo[3.2.1.0*2,4*]oct-6-yl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione | CHEMBL298474 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H24N4O3 |
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| Mol. Mass. | 344.4082 |
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| SMILES | CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)C1CC2CC1C1OC21 |THB:6:17:22.24:20,23:22:20:17.18,23:24:20:17.18| |
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| Structure | 
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