| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent dopamine transporter |
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| Ligand | BDBM50058294 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_61362 (CHEMBL879550) |
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| IC50 | 22±n/a nM |
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| Citation |  Meltzer, PC; Blundell, P; Jones, AG; Mahmood, A; Garada, B; Zimmerman, RE; Davison, A; Holman, BL; Madras, BK A technetium-99m SPECT imaging agent which targets the dopamine transporter in primate brain. J Med Chem40:1835-44 (1997) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium-dependent dopamine transporter |
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| Name: | Sodium-dependent dopamine transporter |
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| Synonyms: | DAT1 | Dopamine transporter | SC6A3_MACFA | SLC6A3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 68455.12 |
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| Organism: | Macaca fascicularis |
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| Description: | ChEMBL_61362 |
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| Residue: | 620 |
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| Sequence: | MSKSKCSVGLMSSVVAPAKEPNAMGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDR
ETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPVLKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHC
NNSWNSPNCSDAHSGDSGGNGPGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQL
TACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSV
DFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSS
GFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGI
DSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAA
GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSI
VTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD
RELVDRGEVRQFTLRHWLKV
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| BDBM50058294 |
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| n/a |
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| Name | BDBM50058294 |
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| Synonyms: | (2R,3S)-3-[Bis-(4-fluoro-phenyl)-methoxy]-8-(3-phenyl-propyl)-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester | CHEMBL300183 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H33F2NO3 |
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| Mol. Mass. | 505.5954 |
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| SMILES | COC(=O)[C@@H]1C2CCC(C[C@@H]1OC(c1ccc(F)cc1)c1ccc(F)cc1)N2CCCc1ccccc1 |TLB:28:27:4.10.9:6.7,11:10:27:6.7,THB:2:4:27:6.7| |
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| Structure | 
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