| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent dopamine transporter |
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| Ligand | BDBM50279764 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_61362 (CHEMBL879550) |
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| IC50 | 343±n/a nM |
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| Citation |  Meltzer, PC; Blundell, P; Jones, AG; Mahmood, A; Garada, B; Zimmerman, RE; Davison, A; Holman, BL; Madras, BK A technetium-99m SPECT imaging agent which targets the dopamine transporter in primate brain. J Med Chem40:1835-44 (1997) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium-dependent dopamine transporter |
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| Name: | Sodium-dependent dopamine transporter |
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| Synonyms: | DAT1 | Dopamine transporter | SC6A3_MACFA | SLC6A3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 68455.12 |
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| Organism: | Macaca fascicularis |
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| Description: | ChEMBL_61362 |
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| Residue: | 620 |
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| Sequence: | MSKSKCSVGLMSSVVAPAKEPNAMGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDR
ETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPVLKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHC
NNSWNSPNCSDAHSGDSGGNGPGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQL
TACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSV
DFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSS
GFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGI
DSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAA
GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSI
VTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD
RELVDRGEVRQFTLRHWLKV
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| BDBM50279764 |
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| n/a |
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| Name | BDBM50279764 |
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| Synonyms: | CHEMBL55730 | Diastereiosomer of[N-[2-[(3'-N'-Propyl-3''alpha-(bis(4-fluororphenyl)methoxy)tropane-2''beta-carboxylic acid methyl ester)(2-mercaptoethyl)amino]acetyl]-2-aminoethanethiolato]rhenium(V) oxide | [N-[2-[(3'-N'-PROPYL-3''ALPHA-(BIS(4-FLUORORPHENYL)METHOXY)TROPANE-2''BETA-CARBOXYLIC ACID METHYL ESTER)(2-MERCAPTOETHYL)AMINO]ACETYL]-2-AMINOETHANETHIOLATO]RHENIUM(V) OXIDE (DIASTEREOMERIC MIX) | [N-[2-[(3'-N'-Propyl-3''alpha-(bis(4-fluororphenyl)methoxy)tropane-2''beta-carboxylic acid methyl ester)(2-mercaptoethyl)amino]acetyl]-2-aminoethanethiolato]rhenium(V) oxide |
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| Type | Small organic molecule |
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| Emp. Form. | C31H38F2N3O5ReS2 |
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| Mol. Mass. | 820.984 |
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| SMILES | COC(=O)[C@@H]1C2CCC(C[C@@H]1OC(c1ccc(F)cc1)c1ccc(F)cc1)N2CCCN1CCS[Re]2(=O)SCCN2C(=O)C1 |TLB:28:27:4.10.9:6.7,11:10:27:6.7,THB:2:4:27:6.7| |
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| Structure | 
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