Reaction Details |
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Target | Histone acetyltransferase KAT2A |
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Ligand | BDBM50506380 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1825679 (CHEMBL4325443) |
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IC50 | >20000±n/a nM |
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Citation | Yang, Y; Zhang, R; Li, Z; Mei, L; Wan, S; Ding, H; Chen, Z; Xing, J; Feng, H; Han, J; Jiang, H; Zheng, M; Luo, C; Zhou, B Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors. J Med Chem63:1337-1360 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone acetyltransferase KAT2A |
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Name: | Histone acetyltransferase KAT2A |
Synonyms: | GCN5 | GCN5 | GCN5L2 | General control of amino acid synthesis protein 5-like 2 | HGCN5 | Histone acetyltransferase GCN5 | Histone acetyltransferase KAT2A | Histone acetyltransferase KAT2A/KAT2B | HsGCN5 | KAT2A | KAT2A_HUMAN | Lysine acetyltransferase 2A | STAF97 |
Type: | PROTEIN |
Mol. Mass.: | 93956.22 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_100876 |
Residue: | 837 |
Sequence: | MAEPSQAPTPAPAAQPRPLQSPAPAPTPTPAPSPASAPIPTPTPAPAPAPAAAPAGSTGT
GGPGVGSGGAGSGGDPARPGLSQQQRASQRKAQVRGLPRAKKLEKLGVFSACKANETCKC
NGWKNPKPPTAPRMDLQQPAANLSELCRSCEHPLADHVSHLENVSEDEINRLLGMVVDVE
NLFMSVHKEEDTDTKQVYFYLFKLLRKCILQMTRPVVEGSLGSPPFEKPNIEQGVLNFVQ
YKFSHLAPRERQTMFELSKMFLLCLNYWKLETPAQFRQRSQAEDVATYKVNYTRWLCYCH
VPQSCDSLPRYETTHVFGRSLLRSIFTVTRRQLLEKFRVEKDKLVPEKRTLILTHFPKFL
SMLEEEIYGANSPIWESGFTMPPSEGTQLVPRPASVSAAVVPSTPIFSPSMGGGSNSSLS
LDSAGAEPMPGEKRTLPENLTLEDAKRLRVMGDIPMELVNEVMLTITDPAAMLGPETSLL
SANAARDETARLEERRGIIEFHVIGNSLTPKANRRVLLWLVGLQNVFSHQLPRMPKEYIA
RLVFDPKHKTLALIKDGRVIGGICFRMFPTQGFTEIVFCAVTSNEQVKGYGTHLMNHLKE
YHIKHNILYFLTYADEYAIGYFKKQGFSKDIKVPKSRYLGYIKDYEGATLMECELNPRIP
YTELSHIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKEGVRQIPVESVPGIRETGWKPLG
KEKGKELKDPDQLYTTLKNLLAQIKSHPSAWPFMEPVKKSEAPDYYEVIRFPIDLKTMTE
RLRSRYYVTRKLFVADLQRVIANCREYNPPDSEYCRCASALEKFFYFKLKEGGLIDK
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BDBM50506380 |
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n/a |
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Name | BDBM50506380 |
Synonyms: | CHEMBL4587968 |
Type | Small organic molecule |
Emp. Form. | C27H23F4N5O4 |
Mol. Mass. | 557.4962 |
SMILES | Cn1cc(cn1)-c1ccc2c(CC[C@]22NC(=O)N(CC(=O)N3Cc4cc(F)ccc4OC[C@H]3C(F)(F)F)C2=O)c1 |r| |
Structure |
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