Reaction Details |
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Target | Tyrosine-protein phosphatase non-receptor type 1 |
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Ligand | BDBM50506667 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1826841 (CHEMBL4326715) |
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Ki | 13100±n/a nM |
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Citation | Maccari, R; Del Corso, A; Paoli, P; Adornato, I; Lori, G; Balestri, F; Cappiello, M; Naß, A; Wolber, G; Ottanà, R An investigation on 4-thiazolidinone derivatives as dual inhibitors of aldose reductase and protein tyrosine phosphatase 1B, in the search for potential agents for the treatment of type 2 diabetes mellitus and its complications. Bioorg Med Chem Lett28:3712-3720 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein phosphatase non-receptor type 1 |
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Name: | Tyrosine-protein phosphatase non-receptor type 1 |
Synonyms: | PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) |
Type: | Protein phosphatase |
Mol. Mass.: | 49963.76 |
Organism: | Homo sapiens (Human) |
Description: | Human recombinant GST-fusion PTP1B (1-435). |
Residue: | 435 |
Sequence: | MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG
IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT
AGAYLCYRFLFNSNT
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BDBM50506667 |
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n/a |
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Name | BDBM50506667 |
Synonyms: | CHEMBL4448571 |
Type | Small organic molecule |
Emp. Form. | C20H17NO5S |
Mol. Mass. | 383.418 |
SMILES | OC(=O)CN1C(=O)S\C(=C/c2cccc(OCCc3ccccc3)c2)C1=O |
Structure |
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