| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity tyrosine-phosphorylation-regulated kinase 4 |
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| Ligand | BDBM50085415 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1828520 (CHEMBL4328394) |
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| IC50 | 4380±n/a nM |
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| Citation |  Narayan, S; Ramisetti, S; Jaiswal, AS; Law, BK; Singh-Pillay, A; Singh, P; Amin, S; Sharma, AK ASR352, A potent anticancer agent: Synthesis, preliminary SAR, and biological activities against colorectal cancer bulk, 5-fluorouracil/oxaliplatin resistant and stem cells. Eur J Med Chem161:456-467 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity tyrosine-phosphorylation-regulated kinase 4 |
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| Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 4 |
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| Synonyms: | DYRK4 | DYRK4_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59629.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1475744 |
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| Residue: | 520 |
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| Sequence: | MPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEILGY
AELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAK
CLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFC
ITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQ
KGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTG
YPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSK
DLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKSNS
FFPSETRKDKVQGCHHSSRKADEITKETTEKTKDSPTKHVQHSGDQQDCLQHGADTVQLP
QLVDAPKKSEAAVGAEVSMTSPGQSKNFSLKNTNVLPPIV
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| BDBM50085415 |
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| n/a |
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| Name | BDBM50085415 |
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| Synonyms: | 3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-dihydro-indol-2-one | 3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one | 3-[1-(3,5-Dibromo-4-hydroxy-phenyl)-meth-(Z)-ylidene]-5-iodo-1,3-dihydro-indol-2-one | CHEMBL72365 | G6416 (GW5074) | GW-5074 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H8Br2INO2 |
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| Mol. Mass. | 520.942 |
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| SMILES | Oc1c(Br)cc(\C=C2/C(=O)Nc3ccc(I)cc23)cc1Br |
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| Structure | 
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