| Reaction Details |
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 | Report a problem with these data |
| Target | Cytosolic phospholipase A2 |
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| Ligand | BDBM50059551 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_156041 (CHEMBL764349) |
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| IC50 | 9000±n/a nM |
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| Citation |  Lehr, M Synthesis, biological evaluation, and structure-activity relationships of 3-acylindole-2-carboxylic acids as inhibitors of the cytosolic phospholipase A2. J Med Chem40:2694-705 (1997) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytosolic phospholipase A2 |
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| Name: | Cytosolic phospholipase A2 |
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| Synonyms: | 1-alkyl-2-acetylglycerophosphocholine esterase | 2-acetyl-1-alkylglycerophosphocholine esterase | CPLA2 | LDL-PLA(2) | Lysophospholipase | PA24A_BOVIN | PAF 2-acylhydrolase | PAF acetylhydrolase | PLA2G4 | PLA2G4A | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 group IVA | Platelet-activating factor acetylhydrolase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 85334.67 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_156041 |
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| Residue: | 749 |
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| Sequence: | MSFIDPYQHIIVEHHYSHKFTVVVLRATKVTKGTFGDMLDTPDPYVELFISSTPDSRKRT
RHFNNDINPVWNETFEFILDPNQENILEITLMDANYVMDETLGTTTFPISSMKVGEKKQV
PFIFNQVTEMILEMSLEVCSSPDLRFSMALCDQEKAFRQQRKENIKENMKKLLGPKNSEG
LHSTRDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYIAGLSGSTWYMSTLYSH
PDFPEKGPEEINKELMKNVSHNPLLLLTPQKIKRYVESLWRKKSSGQPVTFTDIFGMLIG
ETLIHNRMNTTLSSLKEKVNTGQCPLPLFTCLHVKPDVSELMFADWVEFSPFEIGMAKYG
TFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQSKGSTMEEE
LENITAKHIVSNDSSDSDDESQGPKGTEHEEAEREYQNDNQASWVQRMLMALVSDSALFN
TREGRAGKVHNFMLGLNLNTSYPMSPLRDFTMQESLDEDELDAAVADPDEFEQIYEPLDV
KSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMN
KLPFPKIDPYVFDREGLKECYVFKPKNPDVEKDCPTIIHFVLANINFRKYKAPGVPRETN
EEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMYFNTLNNIDVIKNAIVESIEYRR
QNPSRCSVSLSSVEARRFFNKEFLSKPTA
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| BDBM50059551 |
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| n/a |
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| Name | BDBM50059551 |
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| Synonyms: | 6-Chloro-3-dodecanoyl-1-methyl-1H-indole-2-carboxylic acid | CHEMBL90412 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H30ClNO3 |
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| Mol. Mass. | 391.932 |
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| SMILES | CCCCCCCCCCCC(=O)c1c(C(O)=O)n(C)c2cc(Cl)ccc12 |
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| Structure | 
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