Ki Summary

Reaction Details

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Target

Cholecystokinin receptor type A

Ligand

BDBM50060328

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_47650 (CHEMBL657362)

>5000±n/a nM

Citation

Martín-Martínez, M; Bartolomé-Nebreda, JM; Gómez-Monterrey, I; González-Muñiz, R; García-López, MT; Ballaz, S; Barber, A; Fortuño, A; Del Río, J; Herranz, R Synthesis and stereochemical structure-activity relationships of 1,3-dioxoperhydropyrido[1,2-c]pyrimidine derivatives: potent and selective cholecystokinin-A receptor antagonists. J Med Chem40:3402-7 (1997) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Cholecystokinin receptor type A

Name:

Cholecystokinin receptor type A

Synonyms:

CCKAR_RAT | Cckar | Cholecystokinin peripheral | Cholecystokinin receptor | Cholecystokinin receptor type A

Type:

Enzyme Catalytic Domain

Mol. Mass.:

49676.37

Organism:

RAT

Description:

Cholecystokinin central 0 RAT::P30551

Residue:

444

Sequence:

MSHSPARQHLVESSRMDVVDSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSALQI
LLYSIIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLK
DFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICRPLQSRVWQTKSHALKVIAAT
WCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPSDAMQQSWQTFLLLILFLLPGIVM
VVAYGLISLELYQGIKFDASQKKSAKEKKPSTGSSTRYEDSDGCYLQKSRPPRKLELQQL
SSGSGGSRLNRIRSSSSAANLIAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSAE
KHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGVRGEVGEEE
DGRTIRALLSRYSYSHMSTSAPPP

BDBM50060328

n/a

Name

BDBM50060328

Synonyms:

(2R,8S,8aR)-2-Benzyl-8-[(R)-2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-3-oxo-octahydro-indolizine-2-carboxylic acid methyl ester | CHEMBL325070

Type

Small organic molecule

Emp. Form.

C33H40N4O6

Mol. Mass.

588.6939

SMILES

COC(=O)[C@]1(Cc2ccccc2)C[C@@H]2[C@H](CCCN2C1=O)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C

Structure