| Reaction Details |
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 | Report a problem with these data |
| Target | Maternal embryonic leucine zipper kinase |
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| Ligand | BDBM50508584 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1833238 (CHEMBL4333246) |
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| IC50 | 192±n/a nM |
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| Citation |  Boutard, N; Sabiniarz, A; Czerwi?ska, K; Jarosz, M; Cierpich, A; Kolasi?ska, E; Wiklik, K; Gluza, K; Commandeur, C; Buda, A; Stasiowska, A; Bobowska, A; Galek, M; Fabritius, CH; Bugaj, M; Palacz, E; Mazan, A; Zar?bski, A; Krawczy?ska, K; ?urawska, M; Zawadzki, P; Milik, M; W?grzyn, P; Dobrza?ska, M; Brzózka, K; Kowalczyk, P 5-Keto-3-cyano-2,4-diaminothiophenes as selective maternal embryonic leucine zipper kinase inhibitors. Bioorg Med Chem Lett29:607-613 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Maternal embryonic leucine zipper kinase |
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| Name: | Maternal embryonic leucine zipper kinase |
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| Synonyms: | KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK) |
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| Type: | Enzyme |
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| Mol. Mass.: | 74665.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q14680 |
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| Residue: | 651 |
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| Sequence: | MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEA
LKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAV
AYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELI
QGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLL
QQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQT
MEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDV
TASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKL
KNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPI
KIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITV
LTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQT
QSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
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| BDBM50508584 |
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| n/a |
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| Name | BDBM50508584 |
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| Synonyms: | CHEMBL4563315 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H12ClN3OS2 |
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| Mol. Mass. | 325.837 |
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| SMILES | CC(C)Nc1sc(C(=O)c2ccc(Cl)s2)c(N)c1C#N |
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| Structure | 
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