| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dimer of Protein farnesyltransferase subunit beta |
|---|
| Ligand | BDBM50061485 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_68483 (CHEMBL682232) |
|---|
| IC50 | 1300±n/a nM |
|---|
| Citation |  Kaminski, JJ; Rane, DF; Snow, ME; Weber, L; Rothofsky, ML; Anderson, SD; Lin, SL Identification of novel farnesyl protein transferase inhibitors using three-dimensional database searching methods. J Med Chem40:4103-12 (1998) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dimer of Protein farnesyltransferase subunit beta |
|---|
| Name: | Dimer of Protein farnesyltransferase subunit beta |
|---|
| Synonyms: | Protein Farnesyltransferase (PFT) Chain B |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of EBI is 51428 |
|---|
| Components: | This complex has 3 components. |
|---|
| Component 1 |
| Name: | Protein farnesyltransferase subunit beta |
|---|
| Synonyms: | CAAX farnesyltransferase subunit alpha | CAAX farnesyltransferase subunit beta | FNTB | FNTB_HUMAN | FTase-alpha | FTase-beta | GGTase-I-alpha | Protein Farnesyltransferase (PFT) Chain B | Protein farnesyl/geranylgeranyl transferase | Protein farnesyltransferase beta subunit | Protein farnesyltransferase subunit beta | Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Ras proteins prenyltransferase subunit alpha | Ras proteins prenyltransferase subunit beta | Type I protein geranyl-geranyltransferase subunit alpha |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 48766.02 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Protein farnesyltransferase subunit beta |
|---|
| Residue: | 437 |
|---|
| Sequence: | MASPSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFS
SYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQ
IVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDIINREKLLQY
LYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIG
GVPGMEAHGGYTFCGLAALVILKRERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCY
SFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDF
YHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPV
PGFEELKDETSAEPATD
|
|
|
|---|
| Component 2 |
| Name: | Protein farnesyltransferase subunit beta |
|---|
| Synonyms: | CAAX farnesyltransferase subunit alpha | CAAX farnesyltransferase subunit beta | FNTB | FNTB_HUMAN | FTase-alpha | FTase-beta | GGTase-I-alpha | Protein Farnesyltransferase (PFT) Chain B | Protein farnesyl/geranylgeranyl transferase | Protein farnesyltransferase beta subunit | Protein farnesyltransferase subunit beta | Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Ras proteins prenyltransferase subunit alpha | Ras proteins prenyltransferase subunit beta | Type I protein geranyl-geranyltransferase subunit alpha |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 48766.02 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Protein farnesyltransferase subunit beta |
|---|
| Residue: | 437 |
|---|
| Sequence: | MASPSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFS
SYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQ
IVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDIINREKLLQY
LYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIG
GVPGMEAHGGYTFCGLAALVILKRERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCY
SFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDF
YHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPV
PGFEELKDETSAEPATD
|
|
|
|---|
| BDBM50061485 |
|---|
| n/a |
|---|
| Name | BDBM50061485 |
|---|
| Synonyms: | 2-Chloro-3-((2R,3R)-6-chloro-2-imidazol-1-ylmethyl-2,3-dihydro-benzo[b]thiophen-3-yloxymethyl)-pyridine | CHEMBL445906 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H15Cl2N3OS |
|---|
| Mol. Mass. | 392.302 |
|---|
| SMILES | Clc1ccc2[C@@H](OCc3cccnc3Cl)[C@@H](Cn3ccnc3)Sc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
