| Reaction Details |
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 | Report a problem with these data |
| Target | Retinoic acid receptor alpha |
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| Ligand | BDBM50061615 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_197409 (CHEMBL799798) |
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| Ki | 1300±n/a nM |
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| Citation |  Umemiya, H; Fukasawa, H; Ebisawa, M; Eyrolles, L; Kawachi, E; Eisenmann, G; Gronemeyer, H; Hashimoto, Y; Shudo, K; Kagechika, H Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers. J Med Chem40:4222-34 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Retinoic acid receptor alpha |
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| Name: | Retinoic acid receptor alpha |
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| Synonyms: | NR1B1 | Nuclear receptor subfamily 1 group B member 1 | RAR-alpha | RARA | RARA_HUMAN | Retinoic acid receptor alpha | Retinoic acid receptor alpha/Retinoid X receptor alpha | Retinoid X receptor gamma/retinoic acid receptor alpha | Retinoid receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50778.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1466191 |
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| Residue: | 462 |
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| Sequence: | MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPAT
IETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM
VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTL
TPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTV
EFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNA
GFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALK
VYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGL
DTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP
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| BDBM50061615 |
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| n/a |
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| Name | BDBM50061615 |
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| Synonyms: | 4-(10,10,13,13,15-Pentamethyl-11,12,13,15-tetrahydro-10H-8,15-diaza-cyclohepta[2,1-a;4,5-b']dinaphthalen-7-yl)-benzoic acid | CHEMBL298373 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H32N2O2 |
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| Mol. Mass. | 488.6194 |
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| SMILES | CN1c2cc3c(cc2N=C(c2ccc(cc2)C(O)=O)c2ccc4ccccc4c12)C(C)(C)CCC3(C)C |t:9| |
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| Structure | 
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