| Reaction Details |
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 | Report a problem with these data |
| Target | cGMP-specific 3',5'-cyclic phosphodiesterase |
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| Ligand | BDBM50061903 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_155184 (CHEMBL761831) |
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| IC50 | 140±n/a nM |
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| Citation |  Xia, Y; Chackalamannil, S; Czarniecki, M; Tsai, H; Vaccaro, H; Cleven, R; Cook, J; Fawzi, A; Watkins, R; Zhang, H Synthesis and evaluation of polycyclic pyrazolo[3,4-d]pyrimidines as PDE1 and PDE5 cGMP phosphodiesterase inhibitors. J Med Chem40:4372-7 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| cGMP-specific 3',5'-cyclic phosphodiesterase |
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| Name: | cGMP-specific 3',5'-cyclic phosphodiesterase |
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| Synonyms: | PDE5 | PDE5A | PDE5A_BOVIN | Phosphodiesterase 5A |
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| Type: | PROTEIN |
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| Mol. Mass.: | 98615.45 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_155186 |
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| Residue: | 865 |
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| Sequence: | MERAGPGSARPQQQWDQDSVEAWLDDHWDFTFSYFVRKGTREMVNAWFAERVHTIPVCKE
GIKGHTESCSCPLQPSPRAESSVPGTPTRKISASEFDRPLRPIVIKDSEGTVSFLSDSDK
KEQMPLTSPRFDNDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLV
CEDSSNDKFLISRLFDVAEGSTLEEASNNCIRLEWNKGIVGHVAAFGEPLNIKDAYEDPR
FNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFC
GIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIF
IVDEDCSDSFSSVFHMECEELEKSSDTLTRERDANRINYMYAQYVKNTMEPLNIPDVSKD
KRFPWTNENMGNINQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEETTGKVKAFNRNDEQ
FLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPS
AQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCKWILSVKKNYRKNV
AYHNWRHAFNTAQCMFAALKAGKIQKRLTDLEILALLIAALSHDLDHRGVNNSYIQRSEH
PLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIK
RRGEFFELIMKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQG
DRERKELNIEPADLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNR
QKWQALAEQQEKTLINGESSQTKRN
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| BDBM50061903 |
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| n/a |
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| Name | BDBM50061903 |
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| Synonyms: | 3-Benzyl-2,5,7,7-tetramethyl-7,8-dihydro-2H,5H-1,2,5,6,8a-pentaaza-as-indacen-4-one | CHEMBL137712 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H21N5O |
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| Mol. Mass. | 323.3922 |
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| SMILES | CN1C2=NC(C)(C)CN2c2nn(C)c(Cc3ccccc3)c2C1=O |t:2| |
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| Structure | 
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