| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A1 |
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| Ligand | BDBM50061944 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_28838 (CHEMBL649104) |
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| Ki | 840.0±n/a nM |
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| Citation |  Müller, CE; Geis, U; Hipp, J; Schobert, U; Frobenius, W; Pawlowski, M; Suzuki, F; Sandoval-Ramírez, J Synthesis and structure-activity relationships of 3,7-dimethyl-1-propargylxanthine derivatives, A2A-selective adenosine receptor antagonists. J Med Chem40:4396-405 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A1 |
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| Name: | Adenosine receptor A1 |
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| Synonyms: | AA1R_RAT | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | Adenosine A1 receptor (A1) | Adenosine receptor | Adenosine receptors A1 | Adora1 |
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| Type: | Protein |
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| Mol. Mass.: | 36704.13 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | n/a |
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| Residue: | 326 |
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| Sequence: | MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVT
QRRAAVAIAGCWILSLVVGLTPMFGWNNLSVVEQDWRANGSVGEPVIKCEFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFL
KIWNDHFRCQPKPPIDEDLPEEKAED
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| BDBM50061944 |
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| n/a |
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| Name | BDBM50061944 |
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| Synonyms: | 8-((E)-2-Benzo[1,3]dioxol-5-yl-vinyl)-3-methyl-1-prop-2-ynyl-3,7-dihydro-purine-2,6-dione | CHEMBL343527 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H14N4O4 |
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| Mol. Mass. | 350.3282 |
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| SMILES | Cn1c2nc(C=Cc3ccc4OCOc4c3)[nH]c2c(=O)n(CC#C)c1=O |w:6.6| |
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| Structure | 
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