Ki Summary

Reaction Details

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Target

Platelet-activating factor receptor

Ligand

BDBM50048485

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_158348 (CHEMBL768492)

0.400000±n/a nM

Citation

Curtin, ML; Davidsen, SK; Heyman, HR; Garland, RB; Sheppard, GS; Florjancic, AS; Xu, L; Carrera, GM; Steinman, DH; Trautmann, JA; Albert, DH; Magoc, TJ; Tapang, P; Rhein, DA; Conway, RG; Luo, G; Denissen, JF; Marsh, KC; Morgan, DW; Summers, JB Discovery and evaluation of a series of 3-acylindole imidazopyridine platelet-activating factor antagonists. J Med Chem41:74-95 (1998) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Platelet-activating factor receptor

Name:

Platelet-activating factor receptor

Synonyms:

PAF-R | PTAFR | PTAFR_CAVPO | Platelet activating factor receptor | Platelet-activating factor receptor

Type:

Protein

Mol. Mass.:

39005.63

Organism:

Cavia porcellus

Description:

n/a

Residue:

342

Sequence:

MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLT
VADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVK
YPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKG
SKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAV
FVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKF
RKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN

BDBM50048485

n/a

Name

BDBM50048485

Synonyms:

(S)-4-Methyl-2-{methyl-[4-(2-methyl-imidazo[4,5-c]pyridin-1-ylmethyl)-benzenesulfonyl]-amino}-pentanoic acid ethyl ester | 4-Methyl-2-{methyl-[4-(2-methyl-imidazo[4,5-c]pyridin-1-ylmethyl)-benzenesulfonyl]-amino}-pentanoic acid ethyl ester(Lexipafant (BB-882)) | BB-882 | CHEMBL322832 | Lexipafant

Type

Small organic molecule

Emp. Form.

C23H30N4O4S

Mol. Mass.

458.574

SMILES

CCOC(=O)[C@H](CC(C)C)N(C)S(=O)(=O)c1ccc(Cn2c(C)nc3cnccc23)cc1

Structure