| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil collagenase |
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| Ligand | BDBM50062297 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_105205 (CHEMBL713844) |
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| Ki | 0.33±n/a nM |
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| Citation |  Levy, DE; Lapierre, F; Liang, W; Ye, W; Lange, CW; Li, X; Grobelny, D; Casabonne, M; Tyrrell, D; Holme, K; Nadzan, A; Galardy, RE Matrix metalloproteinase inhibitors: a structure-activity study. J Med Chem41:199-223 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil collagenase |
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| Name: | Neutrophil collagenase |
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| Synonyms: | CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL |
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| Type: | Enzyme |
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| Mol. Mass.: | 53413.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22894 |
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| Residue: | 467 |
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| Sequence: | MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIV
EKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNY
TPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGIL
AHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYA
FRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKD
RYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQG
YPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI
ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
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| BDBM50062297 |
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| n/a |
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| Name | BDBM50062297 |
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| Synonyms: | (R)-N*4*-Hydroxy-N*1*-{(R)-1-[2-(4-hydroxy-phenyl)-ethylcarbamoyl]-2-pyridin-4-yl-ethyl}-2-isobutyl-succinamide | CHEMBL302311 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H32N4O5 |
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| Mol. Mass. | 456.5347 |
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| SMILES | CC(C)C[C@H](CC(=O)NO)C(=O)N[C@H](Cc1ccncc1)C(=O)NCCc1ccc(O)cc1 |
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| Structure | 
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